科研项目：
1.国家自然科学基金委员会,青年科学基金项目, 2024-01-01至2026-12-31, 30万元,在研,主持。
2.广东省基础与应用基础研究基金（粤穗联合青年项目）,2022-10-01至2025-09-30, 10万元,结题,主持。
3.中国博士后科学基金会,面上项目, 2022-07-01至2023-12-31, 8万元,结题,主持。
4.广东省基础与应用基础研究基金省市联合基金(粤佛),地区培育项目, 2025-01-01至2027-12-31, 30万元,在研,核心骨干。
5.国家自然科学基金委员会,面上项目, 2023-01-01至2026-12-31, 54万元,在研,参与。
6.国家自然科学基金委员会,面上项目, 2022-01-01至2025-12-31, 58万元,在研,参与。
7.国家自然科学基金委员会,青年科学基金项目, 2019-01-01至2021-12-31, 27万元,结题,参与。
8.国家自然科学基金委员会,面上项目, 2018-01-01至2021-12-31, 60万元,结题,参与。
代表性成果
1.Peng Li#, Xinhai Zhu#, Guangchao Cao#, Ruan Wu, Ke Li, Wenhui Yuan, Biyun Chen, Guodong Sun, Xichun Xia, Hua Zhang, Xiao Wang, Zhinan Yin*, Ligong Lu*, Yunfei Gao*. 1α,25(OH)2D3reverses exhaustion and enhances antitumor immunity of human cytotoxic T cells.Journal for ImmunoTherapy of Cancer. 2022, 10(3): e003477. (第一作者, IF=10.6).
2.Peng Li#,*, Ke Li#, Wenhui Yuan#, Yuqi Xu, Ping Li, Ruan Wu, Jingru Han, Zhinan Yin*, Ligong Lu*, Yunfei Gao*. 1α,25(OH)2D3ameliorates insulin resistance by alleviating γδ T cell inflammation via enhancing fructose-1,6-bisphosphatase 1 expression.Theranostics. 2023, 13(15): 5290-5304. (第一作者/共同通讯作者, IF=13.3).
3. Xinhai Zhu#, Ke Li#, Guichao Liu#, Ruan Wu, Yan Zhang, Siying Wang, Meng Xu*, Ligong Lu*,Peng Li*. Microbial metabolite butyrate promotes anti-PD-1 antitumor efficacy by modulating T cell receptor signaling of cytotoxic CD8 T cell.Gut Microbes. 2023, 15(2): 2249143. (通讯作者, IF=11.0, ESI高被引论文).
4. Ke Li, Eying Lu, Qian Wang, Ruirong Xu, Wenhui Yuan, Ruan Wu, Ligong Lu*,Peng Li*. Serum vitamin D deficiency is associated with increased risk of γδ T cell exhaustion in HBV-infected patients.Immunology. 2024, 171(1): 31-44. (通讯作者, IF=5.0).
5. Dongdong Zhang#, Guichao Liu#, Jinhui Ye#, Ke Li, Guojun Zhang, Qiang Quan*, Xinhai Zhu*,Peng Li*. Low-exhaustion peripheral circulating γδ T cells serve as a biomarker for predicting the clinical benefit rate of non-small cell lung cancer (NSCLC) patients to chemotherapy or targeted therapy: a single-center retrospective study.BMC Cancer. 2025; 25 (178). (通讯作者, IF=3.4)。
6. Guichao Liu#, Qiang Quan#, Lanhong Pan#, Haibo Duan#, Guojun Zhang, Ke Li, Xinhai Zhu*, Dongdong Zhang*,Peng Li*, Jianfu Zhao*. Retinoic acid enhances gammadelta T cell cytotoxicity in nasopharyngeal carcinoma by reversing immune exhaustion.Cell Communication and Signaling. 2025, 23(1):156. (共同通讯作者, IF=8.9).
7.Peng Li#, Ruan Wu#, Ke Li#, Wenhui Yuan, Chuqian Zeng, Yuting Zhang, Xiao Wang, Xinhai Zhu, Jianjun Zhou, Ping Li*, Yunfei Gao*. IDO inhibition facilitates antitumor immunity of Vγ9Vδ2 T cells in triple-negative breast cancer.Frontiers in Oncology. 2021, 11: 679517. (第一作者, IF=3.3).
8.Peng Li#, Wenhui Yuan#, Ruan Wu, Chuqian Zeng, Ke Li*, Ligong Lu*. Androgens in patients with Luminal B and HER2 breast cancer might be a biomarker promoting anti-PD-1 efficacy.Frontiers in Oncology. 2022, 12: 917400. (第一作者, IF=3.3).
9. Xichun Xia#, Guangchao Cao#, Guodong Sun#, Leqing Zhu, Yixia Tian, Yueqi Song, Chengbin Guo, Xiao Wang, Jingxiang Zhong, Wei Zhou,Peng Li, Hua Zhang, Jianlei Hao, Zhizhong Li, Liehua Deng*, Zhinan Yin*, Yunfei Gao*. GLS1-mediated glutaminolysis unbridled by MALT1 protease promotes psoriasis pathogenesis.Journal of Clinical Investigation. 2020, 130(10): 5180-5196. (参与作者, IF=13.6).
10. Hua Zhang#, Guodong Sun#, Xiaowei Li, Zhen Fu, Chengbin Guo, Guangchao Cao, Baocheng Wang Qian Wang, Shuxian Yang, Dehai Li, Xichun Xia,Peng Li, Jing Zhu, Wei Zhou, Liangyan Zheng, Jingxia Li, Lei Zhang, Jianlei Hao, Libing Zhou, Frederic Bornancin, Zhizhong Li*, Zhinan Yin*, Yunfei Gao*. Inhibition of MALT1 paracaspase activity improves lesion recovery following spinal cord injury.Science Bulletin. 2019, 64(16): 1179-1194. (参与作者, IF=21.1).
授权国家发明专利：
1.高云飞,黎鹏,尹芝南,王笑,吴阮,维生素D受体及配体在提高免疫细胞抗肿瘤能力中的应用, 2021-6-11,中国, ZL201910861612.2. (发明专利)。
2.高云飞,尹芝南,黎鹏,郑良焰,维生素顿3或其活性形式1α,25(翱贬)2D3在抑制PD-1表达中的应用, 2021-7-27,中国, ZL201711248940.2. (发明专利)。
会议经历及其他奖励：
2015年获湖北省教育厅优秀学士学位论文奖。
