刘大志,国产手机精品一区二区细胞与基因技术研究院特聘杰出教授,前加州大学戴维斯分校教授;
提出原创学术概念“异常细胞周期疾病(Aberrant Cell Cycle Diseases,ACCD)”,揭示神经系统疾病与癌症的共同病理基础——细胞周期异常。在ACCD 理论框架上,建立学科交融的科研项目“抑癌元素治疗神经系统疾病”,并在此国际前沿领域,保持原创引领。
抑癌元素(抑癌微小核酸增强剂、癌因子/激酶抑制剂)治疗急性脑损伤等神经系统疾病的机制研究与产业转化
2020-2025 教授 加州大学戴维斯分校
2016-2020 副教授加州大学戴维斯分校
2010-2016 助理研究教授加州大学戴维斯分校
2006-2010 博士后加州大学戴维斯分校
2015-2020 NIHR01 激酶Src抑制剂治疗脑损伤
2020-2025 NIHR01 抑癌性微小核酸(microRNA)治疗脑损伤
1.Lui A, Do T, Alzayat O, Yu N, Phyu S, Santuya HJ, Liang B, Kailash V, Liu D, Inslicht SS, Shahlaie K, Liu DZ. Tumor Suppressor MicroRNAs in Clinical and Preclinical Trials for Neurological Disorders.Pharmaceuticals,2024 Mar 27;17(4):426.PMID:38675388
2.Ye Z,Izadi A, Gurkoff GG,RickerlK, Sharp FR, Ander BP,BauerAZ, Lui A, Lyeth BG, LiuDZ. Combined Inhibition of Fyn and c-Src Protects Hippocampal Neurons and Improves Spatial Memory via ROCK after Traumatic Brain Injury.J Neurotrauma.2022 Apr;39(7-8):520-529.PMID:35109711
3.LiuDZ,Lyeth B.Martin R, Shahlaie K.Methods (of Using Abemaciclib)for Treating Brain Injury.(Patent:US2022/051931)
4.LiuDZ,Lyeth B.Martin R, Shahlaie K.Methods (of Using Dasatinib)for Treating Brain Injury.(Patent:US2022/051052)
5.Liu DZ.Methods (of MicroRNA Therapy) for Treating Brain Injury. (Patent:US2019/ 019235)
6.Lv B, Cheng XY, Sharp FR, Ander BP,Liu DZ.Broad therapeutic window of miR-122 mimic to improve stroke outcome through indirect inhibition of NOS2.Front. Neurosci. 2018;12:767.PMID: 30405345
7.Liu DZ,Ander BP, Cell Cycle Inhibition without Disruption of Neurogenesis is a Strategy for Treatment of Aberrant Cell Cycle Diseases: an Update.ScientificWorldJournal. 2012; 2012:491737.PMID: 22547985